Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. <<
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]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" BIOACCUMULATIVE POTENTIAL It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. : CL-611NF Date Approved: 01/13/2010. <>
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Cu:3(]N"AQdUt~h|P The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. PDF (2.77 mb) 2021 FMC Sustainability Report. Avicel PC 611 (FMC Biopolymer) . >>
MATERIAL SAFETY DATA SHEET Version: 1.0 1. The aqueous solution to barrier membrane coating. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. gwf;J(e0o|1p{R~P^);ao!%{0KD7. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . 1 0 obj
The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . pH 6.0 to 8.0 . The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. PDF (4.11 mb) Footer menu 1. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. [FMC Study Number I92-1464]. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Test Data Available. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Buy Chemicals. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. INCI. Watch Now. Product and Company Identification . Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Page 1 of 8. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e
^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w
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Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Aqueous suspensions of microcrystalline cellulose have . It is also inert and biocompatible. Van Veen, G.K. Bolhuis, Y.S. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Quantity: 1 700 kgs. CAS #: 9004-34-6 pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q
c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5
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U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Fiber supplements can lessen the absorption of some . microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. 2008-2023 ChemPoint. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Avicel PC 611 Microcrystalline Cellulose. <>
United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Doses up to 30 g per day appear to be . Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * SUBSTANCE IDENTIFICATION 1.1. The table below shows the most common physicochemical parameters of this raw material. We know that our customers need to provide reliable and consistent products to their patients. ( Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. CoA. It is . The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. endobj
As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Hi, let us know if you have any questions as you visit our website. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. endobj
The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. ChemicalBook. There have always been two different points of view for the liquidity of MCC. Cellulose microcrystalline. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Microcrystalline Cellulose / Avicel PH-102. . Dyvo5bp#bR W7~IF C"
d6zLz~!#>@HO}sx;hm>> It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. No. Validity Area. . <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>>
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The figure below illustrates the structural organisation of cellulose within plants. Powder becomes slippery when wet. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Report Category. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Synonyms: Cellulose, Cellulose powder, Cotton linters. HMo@9, U Q!R/1*;` 1 0 obj
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The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Microcrystalline Cellulose NF. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. High performance lubricant that brings more to the tablet. 130. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. xv}O2' H~KEe9>G/,:9\i This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Catalog Number 102331. 9,LL!z POLYOX resins are nonionic polyethylene oxide solubility polymers. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Micro Crystalline Cellulose. B;vLZpHU%ChUyD+[ Terms and Conditions Compliance Solutions Industries About 3E News & Events . An agricultural sciences company. MATERIAL SAFETY DATA SHEET. Thus, Avicel contributes no or very few calories to the food system. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. <>
Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. endobj
Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. EINECS #: 232-674-9 1.7. No. However, it yields non-digestible fibre. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. : 1. No. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. We are artists at heart and creators by nature. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. X\o^ Chemical Formula: (C6H10O5)n 1.4. Apply today! )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. EMCOCEL XLM 90. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. undefined. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. 8 0 obj Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Gloves, eye protection and a dust mask should be used. zW0}
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3Fz. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. endobj
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Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. The data shown below apply only to Avicel PH 101. Synergies to simplify formulation challenges and reduce operational costs. P}MFbN#[>r(y q9;v80q>jZ Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose.
Phentermine Prescribing Guidelines Ohio, Loyola Academy Board Of Trustees, Articles M
Phentermine Prescribing Guidelines Ohio, Loyola Academy Board Of Trustees, Articles M